Conductasa 30 cap View larger

Conductasa 30 capsulas

Prevention and treatment of deficiencies in vitamin B6, nausea and vomiting, alcohol poisoning or neuromuscular disorders (Parkinson's)

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- [FACTOR VITAMIN], [VITAMIN B]. It is a water soluble vitamin, which is transformed in the body into their active forms pyridoxal phosphate, and to a lesser extent, pyridoxamine phosphate. These forms as enzyme cofactors involved in many biochemical reactions involved in the metabolism of proteins and amino acids, and to a lesser extent in lipid and carbohydrate. Also it participates in the synthesis of nucleic acids, hemoglobin, and seems to influence GABA.

Indications
- [DEFICIT OF VITAMIN B6]. Prevention and treatment of deficiencies in vitamin B6, as in case of improper diet, intestinal malabsorption, hyperthyroidism, stress, prolonged infection or chronic fever, burns. Treatment of conditions due to absence of vitamin B6, and hypochromic anemia.
- [NAUSEA] and [VOMITING]. Treatment and prevention of [NAUSEA AND VOMITING OF PREGNANCY] or [PONV].
- [ACUTE POISONING alcohol].
- Neuromuscular disorders. Treatments of diseases such as [PARKINSON'S DISEASE], [PARKINSONISM], [KOREA] or [QUAKE] Idiopathic.
- [Agranulocytosis], [leukopenia].
- Disorders irradiations.
- Poisoning by isoniazid. Treatment of neurological side effects of isoniazid nature.

Posology
- Adults Oral: 3-6 capsules / day.
- Children, oral: Needs vary with age.
They should be swallowed whole, without chewing, with the help of some liquid.

Contraindications
- Hypersensitivity to any component of the medication.

Precautions
- History of dependencies. Sometimes cases have been reported pyridoxine dependency, greater than 200 mg daily doses are used, so you should monitor patients with a history of dependency.

Warnings / Tips
ADVICE TO THE PATIENT:
- It is not recommended to use vitamin supplements as a substitute for a proper diet.
- Not yet evaluated the effectiveness of administering very high doses of vitamins, so it is not recommended to exceed the recommended doses.
SPECIAL CONSIDERATIONS:
- Pyridoxine deficiency is rare and is usually associated with other vitamin deficiencies.

Interactions
- Antiepileptic medicines (phenytoin, phenobarbital). It has been observed in a study that administration of high doses of pyridoxine (80-200 mg daily) could produce reductions in serum levels of phenytoin and phenobarbital up to 50%, with the risk of seizures. The mechanism of this interaction is unknown, but could be due to induction of metabolism of these medicines by pyridoxine, to participate as a cofactor.
- Levodopa. They described clinical cases of parkinsonism in patients treated with levodopa and receiving a supplement of pyridoxine. In some cases have been observed decreases levodopa plasma concentrations of up to 70%. This effect could be due to increased degradation of levodopa decarboxylase by levo as pyridoxine is involved as a cofactor of this enzyme. It is recommended to avoid this interaction, or, if a supplement pyridoxine necessary, also administer an inhibitor of dopa decarboxylase as carbidopa.

Clinical analysis
- Urobilinogen. False positive results using the method of Ehrlich.

Pregnancy
Category A FDA (category C at high doses). Pyridoxine crosses the placenta and reaches higher concentrations in the fetus than maternal. It could be teratogenic in animals at high doses, but there are no adequate and well controlled studies in humans demonstrate it. Pyridoxine, alone or in combination with doxylamine, it has been used to treat nausea and vomiting during pregnancy. On the other hand, they may be necessary pyridoxine supplements during pregnancy because of severe deficiency or abnormal metabolism is associated with fetal and infantile convulsions and possibly other effects. Therefore, its use is accepted.
However, the use of pyridoxine at very high doses could lead to pyridoxine dependence in the neonate.

Lactation
Pyridoxine is excreted in milk in proportion to maternal intake. Sometimes you may need supplementation to lactating mothers, since a diet low in pyridoxine can lead to seizures in children. Moreover, administration of 600 mg daily appear to inhibit lactation. The American Academy of Pediatrics considers pyridoxine compatible with breastfeeding.

Children
It has not been evaluated the safety and efficacy of the administration of pyridoxine doses exceeding the recommended daily amounts. However, administration of pyridoxine in children with poor diets in this vitamin may be necessary to avoid the appearance of intractable seizures.

Elderly
No specific problems are expected in the elderly.

Adverse reactions
The adverse effects of pyridoxine are mild and transient. Adverse reactions more features are:
- Neurologic / psychological. There have been reports of [DEPENDENCE] to pyridoxine at doses of 200 mg daily for periods exceeding 30 days. may occur rarely (Very rarely, intravenous administration of large doses of pyridoxine has been associated with cases of [SEIZURES].
- Allergic / Dermatological. Rarely

Overdose
Symptoms: The administration of doses greater than 2 g daily for longer periods than 2 months can lead to neuropathic syndromes that present with unsteady gait, weakness of the hands, numbness and perioral numbness, decreased sensitivity to sensations such as touch, temperature or vibration.
Treatment: should be discontinued pyridoxine. Treatment is symptomatic.

Composition
Active ingredient
• Pyridoxine: 153.4 mg.

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