Benerva 300 mg 20 comprimidos View larger

Benerva 300 mg 20 comprimidos

- Treatment of sciatica, back pain, neuralgia, neuritis, facial paralysis, Wernicke syndrome.
- Vitamin B1 Deficiency: Prevention and treatment of beriberi.

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ACTION
- Vitamin B1 is a water soluble vitamin which plays a key role in the metabolism of carbohydrates, part of the cocarboxilasa by the ATP and enzyme tiamin-diphosphokinase. It also participates in the metabolism of proteins and lipids, in the synthesis of acetylcholine and in nerve impulse transmission and in maintaining normal growth.

INDICATIONS
- Deficit Vit B1. Prevention and treatment of beriberi and forms of cardiovascular disorders associated with it.
- Neuritis and polyneuritis. Treatment for sciatica, lumbago, intercostal neuralgia, diabetic neuropathy, optic neuritis, facial paralysis, Wernicke's syndrome, neuritis during pregnancy.

POSOLOGY
DOSAGE:
- Adults and children Oral: 100-200 mg / 24 hours, although in severe cases is 600-1200 mg / 24 hours administered. In Wernicke 300 mg / 24 hours administered.
- Adults and children, intramuscular: 100-200 mg / 24 hours. Injectables are indicated when there is a deficiency in the intestinal absorption or initial treatments of acute deficiencies. When possible, thiamine orally administered.

RULES FOR PROPER MANAGEMENT
- Tablets: They should be swallowed with a little liquid, without chewing or dissolving.
- Blistering: Blisters should be administered intramuscularly. The intravenous route should only be used under special conditions, in hospitalized patients, and when necessary. More often appear hypersensitivity reactions. To avoid this, thiamine should be administered very slowly.

CONTRAINDICATIONS
Hypersensitivity to any component of the medication.

PRECAUTIONS
- Hypersensitivity reactions. Hypersensitivity reactions may be severe, and even fatal, especially when administered intravenously. If they appeared symptoms of hypersensitivity reactions, administration should be discontinued and not restart. They may be administered corticosteroids, antihistamines H1 and vasopressor amines.
- Wernicke. When starting therapy Wernicke syndrome with dextrose infusions of thiamine can lead to a worsening of the picture. It is recommended to administer thiamine alone or with dextrose solutions.
- Thiamine deficiency. Thiamine deficiency is very rare and is usually associated with multiple vitamin deficiency.

ADVICE TO THE PATIENT
- It is not recommended to use vitamin supplements as a substitute for a proper diet.
- Should alert the physician if the patient has itching, dizziness or difficulty breathing.
- Not yet evaluated the effectiveness of administering very high doses of vitamins, so it is not recommended to exceed the recommended doses.

SPECIAL WARNINGS
- Thiamine deficiency is rare and is usually associated with other vitamin deficiencies.
- It is not recommended to use the intravenous route, unless necessary.

INTERACTIONS
Neuromuscular blocking agents. Thiamine may enhance the effects of such agents, but the clinical significance has not been evaluated.

PREGNANCY
Category A FDA (Category C with doses exceeding CDRs). Vitamin B1 is actively transported to the fetus reaching greater concentrations than in the mother. Thiamine deficiency is common during pregnancy, vitamin supplementation is recommended if necessary. Thiamine has been used to control hyperemesis gravidarum, although pyridoxine proved more effective.

LACTATION
Thiamine is excreted in milk in amounts of 100-200 mg daily, which are lower than the recommended daily allowance amounts. However, due to thiamine that the child may receive from other sources, caution is recommended these supplements during lactation.

CHILDREN
No specific problems are expected in this age group.

ELDERLY
No specific problems are expected in this age group.

ADVERSE REACTIONS
Thiamine is usually well tolerated at doses of 100 to 500 mg daily, and only rarely can produce adverse reactions:
- Digestive. Rarely nausea can occur when administered orally.
- Allergic / Dermatological. Rare is the presence of hypersensitivity reactions, which may present with pruritus, dizziness, dyspnea, hypotension, urinary incontinence, and in the most severe cases anaphylaxis and even death.

OVERDOSE
Symptoms: After administration of doses up to 500 mg daily, no toxic effects were found. When administering doses of 500 mg daily for 1 month, hypersensitivity reactions may occur.
Treatment: Treatment is symptomatic. corticosteroids, antihistamines H1 or pressor amines may be administered.

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